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Collectively, these findings establish PKM2 as a pivotal metabolic checkpoint, whose allosteric regulation offers a compelling strategy for immunomodulation by skewing the balance away from pro-inflammatory Th17 responses and toward Treg cell functions

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the selection should be driven by the target outcome

Cancer cells were grown in medium with 13 C-cystine and then switched to cystine-free medium with unlabelled GSH (Fig