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That extra volume is what builds the muscle The phosphocreatine system is especially concentrated in the frontal brain areas involved in working memory and strategic planning The brain makes its own creatine but muscles are greedy for it when you train, so dietary creatine often gets mopped up before reaching the brain At 10 grams a day a German study found via MRI that brain creatine levels increase above what the brain makes on its own

Bemlih S, Poirier MD, El Andaloussi A

So this hormone had a double activity, namely both stimulating insulin secretion and inhibiting glucagon secretion, and that all of a sudden made it interesting because people with diabetes, they have a problem with both insulin and glucagon

Liang R, Ghaffari S (2014) Stem cells, redox signaling, and stem cell aging