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Cascara sagrada is the common name of the California buckthorn (Rhamnus purshianus), a shrub that grows in the Pacific Northwest

Additionally, studies employing cortical pattern matching have shown diminished cortical gray matter thickness in the left anterior cingulate cortex among individuals with T2DM, with those co-diagnosed with major depression exhibiting significant cortical gray matter reductions in bilateral prefrontal areas when compared to healthy controls [102]

This long duration of action is one of the reasons it has generated so much attention in the weight loss research community