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Simultaneously, it engages the glucose-dependent insulinotropic polypeptide receptor (GIPR), which was historically considered metabolically dormant but now recognized for synergistic effects on energy expenditure and weight regulation

This unique combination enhances its ability to regulate appetite, promote satiety, and support weight loss more effectively than medications that only target one pathway

CagriSema combines semaglutide with cagrilintide, an amylin analog, showing 20.4% weight loss in recent Phase 3 trials

The mechanisms of these drugs, which include slowing gastric emptying and signaling fullness to the brain, work synergistically with a high-protein diet to enhance these effects

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