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Rotating injection sites prevents these reactions from accumulating or worsening
Prior, N., Inacio, P
Vitamin B12 is a water-soluble vitamin essential for red blood cell formation, neurological function, and DNA synthesis Requirements vary by age: infants need 0.30.4 mcg daily, children 0.51.2 mcg, and lactating women 2.0 mcg Pernicious anaemia typically requires intramuscular injections of 1,000 mcg hydroxocobalamin, initially three times weekly then every 23 months Deficiency causes macrocytic anaemia and neurological symptoms including paraesthesia, balance problems, and cognitive changes that may become irreversible B12 is found almost exclusively in animal products
the spray format is selected for specific in vivo delivery route research
Neuropathy due to vitamin B12 deficiency primarily affects the posterior columns of the spinal cord, and as it advances, can involve large-diameter myelinated fibers (A) in the peripheral nerves [12]
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