The first GLP-1 analog to be approved by FDA in 2005 for the management of Type 2 diabetes was the chemically synthesized Exenatide under the name of Byetta (186), a formulation of the DPP-IV resistant peptide discovered in the gila monster Heloderma suspectum saliva in 1992 (187)
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Due to having the aforementioned pharmacological actions, acetyl L-carnitine is clinically used to treat depression associated with the primary degenerative disease (Alzheimer's Dementia), is also prescribed to treat the secondary degenerative disease (vascular dementia), and is a broad-spectrum agent which can be used as a first-selective drug ex hibiting excellent ameliorating effects on early- stage dementia patients (The Journal of Applied Pharmacology (2001) 9:285-290)
