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Syndecans consist of conserved cytoplasmic and transmembrane domains and more divergent ectodomains that carry differentially sulfated glycosaminoglycan (GAG) chains 2

When they break down, the degradation products can produce a yellowish tint

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs