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The subsequent SUSTAIN FORTE: This trial confirmed that a higher 2.0 mg dose could achieve even greater A1c reduction compared to the 1.0 mg dose (-2.2% vs -1.9%), providing an additional option for patients needing more intensive glycemic control

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However, functional defects in N-myristoyltransferase (NMT) within T cells of RA patients impede AMPK activation, leading to hyperactivation of the mTORC1 pathway and encourages the proliferation of Th1 and Th17 cells (154)

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