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Although this remains to be confirmed, one possibility is that Ator1, adjacent to the pore-forming domain, binds with the highest affinity, as it requires only minimal conformational changes in RyR1 to allow its binding

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Abramovitz M, Homma H, Ishigaki S, Tansey F, Cammer W, Listowsky I: Characterization and localization of glutathione-S-transferases in rat brain and binding of hormones, neurotransmitters, and drugs

It isnt growth