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B., Ma, Q., Oh, J

who suggested that acetaminophen ingestion depletes intracellular GSH stores, which then causes loss of feedback inhibition of -glutamylcysteine synthetase activity (Figures 3a and 3b).This increases production of -glutamylcysteine, which is partially converted to pyroglutamic acid

When dehydration reduces blood volume, kidney filtration decreases, urine becomes concentrated, and the risk of both kidney injury and urinary infection increases simultaneously