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Taken together, these limitations underscore the need for larger, multicenter randomized controlled trials with longer follow-up periods, standardized interventions, and biomarkers of smoking cessation such as Nicotine Metabolite Ratio [] to more definitively establish the role of GLP-1 RAs in this context

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PMID: 47 HurrellBPSakanoYShenSHelouDGLiMShafiei-JahaniPet al

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Finally, the conclusion will recap the key points discussed, summarize the evidence, and provide a future outlook for the use of semaglutide in back pain management