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i , Inefficiently metastasizing human melanomas were transplanted subcutaneously into NSG mice and the number of melanoma cells per microlitre of blood and tumour-draining lymph were determined ( n = 4 or 5 mice per melanoma from two independent experiments)

Bre1 mediates the ubiquitination of histone H2B by regulating Lge1 stability

10.1038/ni1254 43 HeK.WangZ

Standard minimal inhibitory concentrations (MIC) assays (27) were conducted to determine sensitivity to each chemical, and appropriate concentrations chosen for the remaining experiments