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A U-shaped dose-response and time-of-infusion curve has been documented an important design consideration for DSIP research, as both sub-threshold and supra-threshold doses may produce attenuated effects relative to the optimal dose range

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Using in vivo electrophysiology and behavioral assays in mice, we found that: Psilocybin inhibited serotonin neuron firing via 5-HT2A receptors and induced the head twitch response (HTR), consistent with psychedelic-like activity

Fruergaard Jrgensen acknowledged the criticism, particularly around the firm's failure to accurately communicate the flexible trial design, which raised questions over tolerability, with fewer than two-thirds of patients progressing to the highest dose after 68 weeks