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7.3.2 Biomarker standardization challenges The practical implementation of ferroptosis biomarkers faces difficulties in standardizing measurements of reactive lipid species like MDA and 4-HNE across clinical laboratories, defining clinically validated cut-off values for therapeutic decision-making, and the invasive nature of obtaining optimal samples like BALF for routine monitoring

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Conflicting observations regarding the beneficial and detrimental effects of autophagy post-TBI reflect a time-dependent change in autophagic flow in the injured brain

Additionally, adopting healthy lifestyle practices such as regular exercise, adequate sleep, and stress management can complement the effects of supplementation