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In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition
doi: 10.1016/S0140-6736(19)31149-3 18 GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRELopesRDet al
Consequently, experts suggest erring on the side of caution
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