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Most of these studies have suggested clinically relevant reductions in migraine frequency and severity, but are limited by lack of placebo control (four out of seven studies)

Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain

Instructions for Capsule Opening (If Applicable) Capsules may be opened and contents sprinkled on soft food for patients with swallowing difficulties, provided they are not crushed

You can also get a stool test to check for bacterial toxins

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