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This effect is mediated through actions on appetite-regulating centres in the brain

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For example, vascular injury (e.g., endothelial apoptosis, reduced angiogenesis via VEGF suppression) leads to hypoxia and impaired nutrient supply, 100,102,145,147,148,149 which in turn promotes osteocyte and osteoblast apoptosis, exacerbating bone collapse

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