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Vascular disease resulting in poor perfusion is a common sequel of diabetes, obesity, and atherosclerosis

Cao Y, Qu HJ, Li P, Wang CB, Wang LX, Han ZW: Single dose administration of L-carnitine improve antioxidant activities in human subjects

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While the study establishes a compelling systemic role for SLC25A45 in fuel switching, important questions remain regarding the tissue-specific contributions of this pathway and how carnitine biosynthesis and utilization are differentially regulated across dietary, disease, and sexually dimorphic contexts