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However, a shortage in 2022 spurred competition from compounding pharmacies, and arch-rival Eli Lilly 's (LLY +0.87%) Mounjaro and Zepbound (tirzepatide) have come on strong

Research has also implicated GLP-1R activation in the CNS with neuroprotective effects in Alzheimers disease models, but also suggests that neuropsychological symptoms such as depression can be exacerbated through GLP-1R activation

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Some studies suggest that GIP plays a significant role in regulating lipid metabolism in adipocytes by promoting lipolysis and increasing lipoprotein lipase activity [65]

J Allergy Clin Immunol 2023;151:48593.e11