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ROS are key factors in the regulation of osteoclast differentiation ( Figure 3 )

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Whey Protein Isolate (WPI) , on the other hand, undergoes advanced, intense processing techniques such as cross-flow microfiltration or ion exchange

Activation of this pathway results in protein synthesis, hypertrophy and inhibition of the key ubiquitin ligase atrogin-1 by inactivating Foxo factors[82], IGF-IR also phosphorylates Shc, which subsequently activates the RAS/Raf/MEK pathway leading to cell proliferation and mitogenesis[2]

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