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A single daily injection creates one isolated GH pulse followed by 22+ hours of minimal activity, failing to replicate the bodys natural pulsatile rhythm

For patients with chronic diseases such as RE, quantifying and delineating these risks through large-scale, long-term prospective cohort studies is particularly important

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In clinical practice, drug selection should therefore prioritize factors such as tolerability, safety profile, adherence, cost, and patient preference rather than expecting major differences in cardiovascular efficacy