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The impact of their molecular mechanisms has been evidenced by landmark trials, which have repeatedly demonstrated that certain GLP-1 RAsincluding liraglutide, semaglutide, and dulaglutideare particularly efficacious in reducing MACE, especially in patients with established ASCVD

We also refer readers to several recent reviews for further reading 1,7,28

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The antibody simtuzumab, targeting extracellular LOXL2, has undergone clinical trials in combination with gemcitabine for patients with metastatic pancreatic adenocarcinoma or with FOLFIRI (folinic acid, fluorouracil, and irinotecan) for patients with KRAS mutant colorectal cancer [102, 103]