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Many patients report improvement in symptoms over time as their body adapts to the medication

But originally, they were mostly for diabetes, is my understanding

2018 ESC/ESH guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension

Knudsen LB et al

Yes, your maintenance dose might need adjustment as your diabetes progresses or your health status changes