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Research remains in early stages with no human clinical trials currently approved

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Accordingly, the main action of semaglutide is to enhance glucose-dependent insulin biosynthesis and secretion through a cAMP-dependent PKA mechanism by conveying two insulin signaling pathways: the PI3K/PKA/mTOR in -cells and the PI3K/AKT along with the AMPK/SIRT1 pathway [20]

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