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Fatigue: Both tirzepatide and liraglutide can cause tiredness, particularly during early treatment and dose escalations
An analog like IGF-1 LR3 that binds IGFBPs poorly does not join the large protected reservoir, but the fraction that is free and bioactive is dramatically higher, and critically in laboratory and animal systems that free analog is not being continually captured and buffered by binding proteins
Aspiration and regurgitation risk With as many articles agreeing on the risks of delayed gastric emptying and increased residual gastric contents among GLP-1 RA users, a similar proportion of articles disagreed on the additional risk of aspiration or regurgitation events
While iron chelators have demonstrated efficacy in treating transfusion-associated iron overload in thalassemia patients, their cardiovascular applications remain predominantly experimental (24, 66)
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