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93 % of patients achieved more than 10% weight loss compared to 9% on lifestyle changes alone 83% of patients achieved more than 15% weight loss compared to 2% on lifestyle changes alone

The agency notes that its not always possible to estimate the frequency of these reactions since they are voluntarily reported

PMID 12183643

This titration minimises gastrointestinal side effects whilst allowing the body to adapt

3 Conclusion While the mechanisms underlying hormone secretion from L cells and their functions in the context of digestion and metabolism are well studied, their role in the pathogenesis of intestinal inflammation is virtually unknown