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It is plausible that GLP-1 agonists could decrease reward (i.e., pleasure) and cravings for addictive substances. Plausible, but not confirmed

This conformation may also be representative of the peptide agonist conformation of GCGR and other class B GPCRs, although previous models of GLP-1R suggested a more tilted conformation of the ECD relative to the plane of the membrane in the GLP-1-bound state 23,24

In LUKE Health, this is enforced at the database level with dual-layer triggers it cannot be bypassed through the UI, API, or any other channel

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The fold change in expression of each gene was calculated using the comparative DDCt method, with GAPDH as housekeeping reference endogenous control