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(20) conducted a study on mice, revealing that oxidative stress damage in aged oocytes results in diminished expression of protein phosphatase 2A (PP2A) at the centromere, reduced dephosphorylation of the Rec8 protein, compromised protection mechanisms of adhesion proteins within the oocyte, inhibition of oocyte division and maturation, and the emergence of aneuploidy

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NRF2 plays a critical role in this process by upregulating the expression of genes involved in the synthesis of -GC, thereby increasing the overall production of GSH [34]

So if you're pregnant, you can't get Glutathione. Still, anyone with underlying conditions like asthma, kidney disease, or sensitivities to sulfur-containing compounds should consult a healthcare provider before use