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To determine if P-gp expression levels predicts the degree of collateral sensitivity to tamoxifen, and the role of P-gp ATPase activity, two drug resistant cell lines (e.g., CHO R C5 and MDA-Doxo 400 ) expressing different levels of P-gp were allowed to proliferate in the presence of increasing concentrations of tamoxifen, without or with specific inhibitor of P-gp-ATPase activity (PSC-833 [33];)