Treatment of B6 mice with the GLS1 inhibitor BPTES significantly reduced histological scores in the spinal cord of affected animals, lowered the number of CD4 + T cells, IL-17A and IFN-producing CD4 + T cells in the spinal cord, substantially decreased clinical scores and weight loss, and ameliorated experimental autoimmune encephalomyelitis ( + CD4 - CD8 - cells), the urinary albumin/creatinine ratio, glomerular nephropathy score, and T-cell infiltration with IL-17A in the kidneys, relieving the EAE disease activity ( + T cells by inhibiting GLS1, glycolysis, and CD4 + T-cell differentiation in vitro by reducing the level of HIF1 protein, a key metabolic sensor in Th17 cells ( Table 1 )
Nature 2009;458:762-5
The main site of neurodegeneration is the thoracic spinal cord
Free radicals are unstable molecules that can damage your cells
The impaired mitochondrial function may lead to an abnormal increase in ROS production while the cellular capacity to eliminate ROS diminishes, significantly increasing intracellular oxidative stress levels (Zhao et al., 2022)
