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Topical use is low-risk enough that its not strictly necessary, but its good practice to mention any new product or supplement to your prescriber

Several techniques have been developed for the evaluation of the BBB such as the in vivo brain uptake index (BUI) method (88), in situ brain perfusion (89), cerebral microdialysis technique (90, 91), and cell uptake studies in the in vitro models of the BBB (92)

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This can be beneficial for brain repair and regeneration in conditions where neuronal loss has occurred, such as neurodegenerative diseases and neurological diseases