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These include the regulation of inflammation, promotion of cell migration and fibroblast proliferation, stimulation of collagen synthesis, enhancement of angiogenesis, and remodeling of the ECM 24 , 32 - 36 , 58 - 60
It was originally isolated from human gastric juice, where it appears to play protective roles for the digestive tract
They utilized a 30-degree tail suspension and isolation (TSI) model that kept the animals hindlimbs off the ground for 28 days to simulate microgravity
2N, O), likely due to the inherent saturation of lipid peroxidation in the absence of DDX3X