Finally, long-term tirzepatide treatment significantly raised BAT levels of several TCA cycle intermediates, including fumarate, malate, and -ketoglutarate
doi: 10.1002/oby.21577 243 NunnEJaiswalNGavinMUeharaKStefkovichMDrareniKet al
504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis
Impacts of glucagon-like peptide-1 receptor agonists on the risk of adverse liver outcomes in patients with metabolic dysfunction-associated steatotic liver disease cirrhosis and type 2 diabetes
In simple terms: your body is making insulin, but your cells arent listening