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This GLP-1 weight loss medications guide compares the two options with those practical questions in mind

However, contact your GP if cold intolerance is severe, impacts daily activities, or is accompanied by symptoms such as fatigue, hair loss, bradycardia, or muscle weakness, as these may indicate underlying conditions requiring investigation

Retatrutide, a triple agonist targeting gastric inhibitory polypeptide (GIP), GLP-1, and glucagon receptors, has achieved highly promising outcomes in its phase 2 trial [22], with weight loss up to 24%

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