Retatrutide, as a newer compound, has less long-term body composition data available
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Coexisting metabolic disorders, including obesity and type 2 diabetes, further modulate ECM remodeling by promoting insulin resistance, lipid dysregulation, and low-grade inflammation (116)
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When paired with a GLP-1 receptor agonist like tirzepatide, which supports satiety and glucose control, the combination may create a synergistic effect for some individuals. However, she cautions that this isnt a one-size-fits-all treatment, and decisions regarding menopausal hormone therapy and GLP-1s must be personalized and considered in consultation with a licensed provider
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