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Persistent symptoms warrant reassessment rather than automatic dose escalation

Janati S, Behmanesh MA, Najafzadehvarzi H, Kassani A, Athari N, Poormoosavi SM (2022) Changes of serum level of homocysteine and oxidative stress markers by metformin and inositol in infertile women with polycystic ovary syndrome: a double blind randomized clinical trial study

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This essentially mirrors results seen with retatrutide which also caused extremely large drops in blood pressure in hypertensive patients with a much more muted effect in normotensive patients

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