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By the time you reach 8mg, your GI system has adapted through two previous escalation cycles, and a 50% increase is proportionally less disruptive than the doublings at lower levels

If more fat is being efficiently converted to fuel, there is less metabolic pressure to cannibalize muscle tissue

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Bao et al (60) found downregulation of the ferroptosis regulator GPX4 in both Fpnfl/fl/NEXcre (NEX-Cre mice were mated with Fpn-floxed (Fpnfl/fl) mice to generate conditional Fpnfl/fl/NEXcre mice.) and APPswe/PS1dE9 (Carrying genetically modified mice with AD-related mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9) mouse models compared with controls