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Participants were assigned to receive weekly doses of retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg for 48 weeks, or placebo

292 The interaction between mechanical forces and cellular mechanotransduction mechanisms, such as the integrin-mediated activation of focal adhesion kinase (FAK) and the subsequent activation of the MAPK/ERK pathway, plays a crucial role in ligament adaptation and repair

Patients should carefully follow dosing instructions provided by their prescribing clinician and compounding pharmacy, and contact their provider immediately if unsure about proper dosing

SP powder was purchased from the Macklin Biochemical Technology (Shanghai, China)