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Journal of Alzheimers Disease, 61(3), 947961

The same 2020 research review that found no evidence of benefits identified numerous serious adverse effects, ranging from uncomfortable to life-threatening

After treatment with myo-inositol (MYO) in combination with alpha-lipoic acid (ALA), levels of HMGB1 in adolescents with PCOS have been found to return to normal (103)

Consistency beats perfection

Due to the nature of these medications as intended to be used long term, many employers have found the commitment to the current high price tag and uncertain future for the unit cost of the drug to be daunting or simply untenable