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The average patient age was 75 years (range: 23 to 102 years)

Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency: A randomised, placebo-controlled study

But as you saw, the scientific literature shows that treatment with massive doses of B12, leading to very high blood levels, is 100% safe

Vitamin B12 is an essential nutrient required for the proper functioning of the body