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With the exceptions of exotoxins secreted by enteropathogenic bacteria, such as the clostridial exotoxins or botulinum exotoxins discussed below, most endotoxins of commensal bacteria are not absorbed by the intact intestine of healthy individuals [49, 55]

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Changes in MtDNA copy number in senescent oocytes The prevalence of infertility, spontaneous abortion, and congenital disabilities has increased in recent years with increasing reproductive age in women, and the core pathologic basis of these reproductive outcomes lies in the decline in developmental potential triggered by damage to the quality of oocytes [46, 47]

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Hcy maintains homeostasis relative to variation in the model If GSH is independent of MS activity in the metabolic network (Figures 1, 5B), this implies that the intervening metabolites must influence this relationship significantly