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Here, they undergo incomplete, alternative oxidation pathways that generate massive amounts of free radicals and reactive oxygen species (ROS), further damaging the delicate mitochondrial membranes and the very enzymes required for energy production

In SH-SY5Y cells treated with BSA-PC, phosphorylation of the mitochondrial fission marker dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF) fragments increased compared to cells treated with BSA alone (Fig 3A and 3B)

The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron

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