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Dose reduction for maintenance Some researchers step down their dose after reaching target weight

doi: 10.1038/sj.jcbfm.9600234

5.2 Reduction of oxidative stress and endoplasmic reticulum stress Chronic hyperglycemia and endothelial activation drive excessive generation of ROS, promoting mitochondrial dysfunction, endothelial apoptosis, and reduced NO bioavailability

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