The activity of this enzyme in the ovary could be a double-edged sword: on the one hand, the NADPH-dependent metabolism of DOX into doxorubicinol by CBR1 allows for the subsequent conjugation and excretion of this drug, and in doing so could deplete NADPH levels needed for the regeneration of GSH needed to neutralise ROS
Biomed Pharmacother 153:113491 Zahid MT, Idrees M, Ying W, Zaki AH, Abdullah I, Haiying B (2020) Review of chemical constituents and pharmacology of brown-rot fungus Fomitopsis pinicola
Store at 20 C for long-term preservation, protected from light and moisture
Avoiding fast food, heavy sauces, and buttery dishes is often the first step in symptom management
The standard schedule increases the dose every four weeks, from 0.25 mg up to the 2.4 mg maintenance dose over about 16 weeks