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Talavera EM, Zafra MF, Gil-Villarino A, Prez M.I, Alvarez JM, Garca-Pelegrin F

Crucially, pharmacological inhibition of CFTR in the PDECs (using CFTRinh-172) led to a ~54% reduction in insulin secretion from the underlying islets, whereas direct application of inhibitor to islets alone had no effect, underscoring a ducto-insular cross-talk mediated by CFTR function

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Lip C injection dosing typically begins at 0.20.5 mg and escalates in weekly or bi-weekly increments toward therapeutic ranges of 2.03.0 mg