doi:10.1530/eje.0.1390552 (source) National Center for Biotechnology Information
Inhibition of either system leads to increased levels of -synuclein, and some evidence suggests that there is compensatory crosstalk between the two systems
He Q, Wu J, Wang X, Luo F, Yan K, Yu W, et al
This bidirectional regulation suggests sophisticated sensing of tissue microenvironmental cues, enabling GHK-Cu to normalize MMP activity toward homeostatic levels rather than exerting uniform stimulatory or inhibitory effects
Lewy bodies have also gained a lot of attention as to their specific distribution in neurons, and increases in their amount are consistent with both PD progression and neurodegeneration (Bethlem and Den Hartog Jager, 1984