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Fill up a reusable water bottle and take plenty of drinks to keep your body hydrated until this side effect passes

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What is established is that its pharmacokinetic profile supports once-weekly dosing, achieved through a C20 fatty diacid moiety that binds to serum albumin the same strategy used by semaglutide and tirzepatide, both of which have half-lives of approximately 5-7 days

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Participants taking the highest 12 mg dose of retatrutide lost an average of 28.3% of their body weight (31.9 kg) over 80 weeks, while those on the lowest 4 mg dose lost an average of 19.0% of their body weight (21.4 kg)