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and the fact that mal-absorption doesn't mean the same as no absorption

They are being investigated for a wide range of diseases, including cancer [4], metabolic disorders [5], autoimmune conditions [6], and wound healing [7, 8]

Rather than manipulating individual pathways in isolation, effective intervention will likely require coordinated, context-dependent modulation of chaperones, autophagy, UPS activity, and ER stress responses

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Specifically, the supplementation of Faecalibacterium prausnitzii or butyrate precursors (such as resistant starch) can effectively restore the levels of SCFAs, reinforce gut epithelial integrity, and reduce systemic inflammation (Miquel et al., 2013