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In addition to melatonin-related mechanisms, there is growing interest in uncovering the role played by circadian clock genes (such as CLOCK, BMAL1, PER1/2/3, CRY1/2, and NPAS2), which not only govern circadian timing but also regulate processes central to tumorigenesis, including cell cycle control, DNA damage response, metabolism, and immune regulation 25

doi: 10.1001/JAMA.2022.11691 189 LedfordH

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