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DDX27 binds with NPM1 (nucleophosmin1) to interact with NF-B in the nucleus leading to increased binding of NF-B to the target gene promoters, triggering enhanced expression of VIMENTIN and SLUG, thereby promoting metastasis in CRC

To begin the evaluation of this idea, we used a 3 H-Hinge peptide as a probe to assess direct HGF binding of the peptides

Given that both of these studies were in patients with OA of the knee (a load-bearing joint), it is likely that a significant proportion of the efficacy observed was due to the significant loss of body weight, reducing pathological joint loading

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[1] [3] These areas have altered tissue architecture that may predispose to reactions